Arrestin-dependent angiotensin AT1receptor signaling regulates Akt and mTor-mediated protein synthesis

Abstract

Background: Angiotensin AT1receptors use G protein-independent signals to stimulate protein synthesis. Results: Arrestin-dependent activation of ERK1/2 and Akt signaling regulates mTOR-p70/85S6K and p90RSK, leading to increased protein translation in HEK293 and primary vascular smooth muscle. Conclusion: Arrestin-dependent ERK1/2 and Akt signaling cooperatively regulate cell growth. Significance: Arrestin pathway-selective AT1 receptor agonists stimulate Akt-mTOR signaling and protein translation.