The evaluation of the correct use and ease-of use of the ELLIPTA DPI in children with asthma

1Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Rationale: Asthma studies show many children use inhalers incorrectly even after instruction. For two age groups of children with asthma, we determined the proportions who used the once-daily ELLIPTA dry-powder inhaler (DPI) correctly, and who found it easy to use. Methods: This was a multicenter, single-arm, stratified, open-label, placebo study (NCT03478657). Children aged 5–7 and 8–11 years were trained in, and required to demonstrate, correct placebo ELLIPTA DPI use at their first clinic visit. The inhaler was used at home once daily for 28 ± 2 days. On returning to the clinic, children were randomized to an age-appropriate, ease-of-use questionnaire that had been developed and validated previously, and which rated the inhaler as “easy” or “hard” to use. Following questionnaire completion, children were then asked to demonstrate correct inhaler use. Correct use and ease-of use were assessed in each age group (co-primary endpoints) and overall (secondary endpoints). Results: Of 222 enrolled children, 221 completed the study. Among children aged 5–7 years, 92% (n = 81/88) demonstrated correct ELLIPTA use on their first attempt, compared with 93% (n = 124/133) aged 8–11 years. Of these children, 98% (5–7 years: n = 79/81; 8–11 years: n = 121/124) rated the inhaler easy to use. Overall, 93% (n = 205/221) demonstrated correct inhaler use on their first attempt, and 98% (n = 200/205) rated it easy to use. Conclusion: ELLIPTA DPI was used correctly and easily by most children on their first attempt without additional training.

References Powered by Scopus

Inhaler mishandling remains common in real life and is associated with reduced disease control

809Citations
N/AReaders
Get full text

Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD

507Citations
N/AReaders
Get full text

Vital signs: Asthma in children — United States, 2001-2016

373Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Dry-powder inhaler use in primary school-aged children with asthma: a systematic review

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Halverson, P., Liem, J., Heyes, L., Preece, A., Bareille, P., Rees, J., … Sharma, R. (2021). The evaluation of the correct use and ease-of use of the ELLIPTA DPI in children with asthma. Pediatric Pulmonology, 56(1), 57–64. https://doi.org/10.1002/ppul.25149

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

40%

Researcher 2

40%

Professor / Associate Prof. 1

20%

Readers' Discipline

Tooltip

Neuroscience 2

33%

Medicine and Dentistry 2

33%

Pharmacology, Toxicology and Pharmaceut... 1

17%

Environmental Science 1

17%

Save time finding and organizing research with Mendeley

Sign up for free