Formulation and Evaluation of Nanosponges-loaded Gel of Lornoxicam for Topical Delivery

Abstract

Nanosponge loaded gels are novel drug delivery system that combine the advantages of achieving optimum concentration of drug at site of action and reduction in systemic side effects. The objective of the present study was to formulate and evaluate gel loaded with nanosponges of Lornoxicam for topical delivery. Lornoxicam nanosponges were prepared successfully using ethyl cellulose as polymer, polyvinyl alcohol as cross-linking agent and dichloromethane as solvent by emulsion solvent diffusion method, which undergo analysis of drug entrapment efficiency, surface morphology, particle size analysis and zeta potential. Among all 6 different formulations, F5 batch was considered as the best with 89% of drug entrapment efficiency and least particle size. From the SEM analysis it was found that nanosponges are spherical, discrete with smooth surface. The nanosponge of the best formulation F5 was loaded into the Carbopol 394P gel which was evaluated for viscosity, spreadability, pH, drug content, in vitro drug diffusion study, release kinetics and stability studies. From the study it was found that the prepared Lornoxicam nanosponge topical gel shows promised drug release and good stability.