Is primary tumor detectable in prostatic carcinoma at routine contrast-enhanced CT?

Abstract

Objectives: To determine if prostatic carcinoma (PCa) is detectable at routine contrast-enhanced CT (CECT). Materials and Methods: With institutional review board approval, 63 consecutive PCa patients underwent CECT before therapy. Two blinded radiologists assessed for rounded focal enhancing peripheral zone nodules. Diagnostic accuracy and inter-observer agreement were compared by Gleason Score (GS). Results: Overall sensitivity was 63-76% with moderate agreement, K= 0.42. The false-positive rate was 15%. Sensitivities and agreement for GS 9-10, 7-8 and 6 PCa were 84-91%, 73-84%, 41-71%, ( P= .023 and .001) and K=(0.72, 0.69, 0.23). Conclusions: CECT has good sensitivity for detecting GS ≥. 7 PCa with substantial agreement and a low false-positive rate.