Salivary microRNA profiling dysregulation in autism spectrum disorder: A pilot study

3Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

Introduction: Autism spectrum disorders (ASD) are the most prevalent neurobiological disorders in children. The etiology comprises genetic, epigenetic, and environmental factors such as dysfunction of the immune system. Epigenetic mechanisms are mainly represented by DNA methylation, histone modifications, and microRNAs (miRNA). The major explored epigenetic mechanism is mediated by miRNAs which target genes known to be involved in ASD pathogenesis. Salivary poly-omic RNA measurements have been associated with ASD and are helpful to differentiate ASD endophenotypes. This study aims to comprehensively examine miRNA expression in children with ASD and to reveal potential biomarkers and possible disease mechanisms so that they can be used to improve faction between individuals by promoting more personalized therapeutic approaches. Materials and methods: Saliva samples were collected from 10 subjects: 5 samples of children with ASD and 5 from healthy controls. miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system. Results: Preliminary data highlighted the presence of 365 differentially expressed miRNAs. Pathway analysis, molecular function, biological processes, and target genes of 41 dysregulated miRNAs were assessed, of which 20 were upregulated, and 21 were downregulated in children with ASD compared to healthy controls. Conclusion: The results of this study represent preliminary but promising data, as the identified miRNA pathways could represent useful biomarkers for the early non-invasive diagnosis of ASD.

References Powered by Scopus

This article is free to access.

This article is free to access.

This article is free to access.

Cited by Powered by Scopus

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kalemaj, Z., Marino, M. M., Santini, A. C., Tomaselli, G., Auti, A., Cagetti, M. G., … Tartaglia, G. M. (2022). Salivary microRNA profiling dysregulation in autism spectrum disorder: A pilot study. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.945278

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

83%

Researcher 1

17%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

44%

Neuroscience 2

22%

Environmental Science 2

22%

Computer Science 1

11%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free