Randomised field trial to evaluate serological response after foot-and-mouth disease vaccination in Uttar Pradesh, India

Abstract

Vaccination was done in 6 villages in Mathura by oil adjuvant FMD trivalent vaccine, selecting twenty cattle and buffaloes from each village for the study. Pre and post vaccination serum samples were tested for antibody against O, A and Asia-1 serotype by sdLPB- ELISA. The overall percent of animals demonstrating protective antibody titre against FMDV serotypes O, A and Asia-1 in pre-vaccinated animals was 65.8, 53.3 and 49.2%, respectively. A significant rise in herd protection level was noticed after vaccination as the percentage of animals protected against serotypes O, A and Asia-1 virus was 78.3, 67.5 and 74.2%, respectively. A higher level of anti 'O' antibody was observed both in pre and post vaccinated serum samples in comparison to serotype A and Asia-1. There was a significant rise in the percent of animals with protective titre for all the three serotypes from 31.6% for pre-vaccinated samples to 63.3% for post vaccination samples.