Synthesis, characterization and antimicrobial activity of novel pyrrolidine-3-carbonitrile derivatives

Abstract

NEWLY synthesized pyrrolidine-3-carbonitrile derivatives were evaluated as antimicrobial activity. The structures of these derivatives were derived from reactions of 1-(4-methoxyphenyl)-4-oxopyrrolidine-3-carbonitrile (1) with the stabilized phosphorus ylides, Wittig-Horner reagents, trialkylphosphites, as well as tris(dialkylamino)phosphines. The antimicrobial activity of the synthesized compounds was evaluated against Gram positive, Gram negative bacteria and fungi. The results showed comparable antibiotic activity to the reference antibiotic compound used in the study.