Effects of 3’-Deoxyadenosine (Cordycepin) on the Repair of X-Ray-Induced DNA Single- and Double-Strand Breaks in Chinese Hamster V79 Cells

Abstract

Cordycepin/3’-deoxyadenosine/DSB/SSB/DNA repair The ability of cordycepin to inhibit the repair of DNA strand breaks was examined with X-irradiated Chinese hamster V79 cells in log-phase culture. A filter elution technique revealed that 70μM cordycepin did not inhibit the repair of single-strand breaks but inhibited the repair of double-strand breaks. These findings confirmed the fact that the increase in the lethality of cordycepin in X-irradiated cultured mammalian cells was attributable to unrepaired DNA double-strand breaks. © 1990, Journal of Radiation Research Editorial Committee. All rights reserved.