Stem Cell Quiescence versus Senescence: The Key for Healthy Aging

Abstract

BACKGROUND: Aging tissues lose their homeostatic and regenerative capacities, which hasbeen linked to the degeneration of the stem cellssuch as the tissue-specific stem cells, the stem cell niches,and systemic cues that regulate stem cell activity.CONTENT: The maintenance of tissue homeostatic andregeneration dependent on its tissue-specific stem cells,that —long-lived cells with the ability to self-renew anddifferentiate into mature cells. Understanding the molecularmechanisms that governs stem cell survival, self-renewal,quiescence, proliferation, and commitment to specificdifferentiated cell lineages is critical for identifying thedrivers and effectors of age-associated stem cell failure.Such understanding will be critical for the developmentof therapeutic approaches that can decrease, and possiblyreverse and repair the age-related degenerative process inaging tissues.SUMMARY: The exact mechanisms and reasons of agingprocess were not fully elucidated until now. Stem cells is oneof the keys for maintaining tissues heath and understandinghow stem cell decline with age will give us opportunities tofind strategy in increasing somatic stem cells regenerativecapacity and delay the aging process