Abstract
Purpose: To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). Materials and methods: FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated. Results: Progressive gliomas had higher SUVmax (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBRmax (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmax < 2.0 compared to tumors with TBRmax > 2.0 (665 ± 32 days versus 220 ± 39 days; p < 0.001). Conclusion: FET-PET uptake might be associated with disease progression in adult BSG.
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Albatly, A. A., Alsamarah, A. T., Alhawas, A., Veit-Haibach, P., Buck, A., Stolzmann, P., … Huellner, M. W. (2018). Value of 18F-FET PET in adult brainstem glioma. Clinical Imaging, 51, 68–75. https://doi.org/10.1016/j.clinimag.2018.01.015
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