A convenient access to biquinoline carbaldehydes using nickel-phosphine complex-mediated homocoupling of haloquinoline carbaldehydes in one-pot reaction

Abstract

The homocoupling of 2-chloro-carbaldehyde derivatives gave the corresponding 2,2'-biquinolines by using the in situ generated reactive reagent Ni[(PPh3)]4. Several new 2-chloro-3-(1.3 dioxalan-2yl) quinoline derivatives are synthesized and structurally characterized. The overall structures of biquinoline derivatives are not planar.