Soluble Biomarkers for Prediction of Vascular and Gastrointestinal Disease Severity in Patients with Systemic Sclerosis

Abstract

Abbreviations ACA anticentromere antibodies _ ANA antinuclear antibody _ anti-AT1R angiotensin II type 1 receptor antibody _ anti-RNA pol III anti-RNA polymerase III antibody _ anti-Scl-70 anti-topoisomerase I antibody _ anti-Th/ To anti-Th/To antibody _ anti-U1-RNP anti-U1 ribonucleoprotein antibody _ anti-U3-RNP anti-U3 ribonucleoprotein antibody _ BMI body mass index _ CI cardiac index _ CCL18 CC motif ligand 18 _ CCL21 CC motif ligand 21 _ CD144+ EMP (VE-cadherin) CD144+ endothelial microparticle (vascular endothelial cadherin) _ CRP C-reactive protein _ CXCL4 (PF4) C-X-C motif ligand 4 or platelet factor 4 _ CTD connective tissue disease _ dcSSc diffuse cutaneous systemic sclerosis _ DU digital ulcer _ ECHO echocardiogram _ ELF score enhanced liver fibrosis score _ ELISA enzyme-linked immunosorbent assay _ EMP endothelial microparticles _ EPC endothelial progenitor cell _ ESR erythrocyte sedimen-tation rate _ ET-1 endothelin-1 _ F-calprotectin fecal calprotectin _ FSTL3 follistatin-like 3 _ FVC forced vital capacity _ IL-6 interleukin 6 _ ILD interstitial lung disease _ KL-6 Krebs von den Lungen 6 _ lcSSc limited cutaneous systemic sclerosis _ mPAP mean pulmonary arterial pressure _ MDK midkine _ NT-proBNP N-terminal pro-brain natriuretic peptide _ PH-ILD pulmonary hypertension secondary to ILD _ PI pulsatile index _ PlGF placental growth factor _ RHC reactive oxygen species _ RVSP right ventricular systolic pressures _ Flt-1 soluble fms-like tyrosine kinase-1/soluble plasma VEGF receptor 1 _ SPAP systolic pulmonary artery pressure _ SP-D surfactant protein D _ SRC scleroderma renal crisis _ SSc-ILD systemic sclerosis-related interstitial lung disease _ SSc-PAH systemic sclerosis-related pulmonary arterial hypertension _ SvO2 mixed venous saturation _ TGF-β transforming growth factor beta _ UA uric acid _