Persistent post-thyroidectomy hypoparathyroidism: A multicenter retrospective cohort study

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Abstract

Background and objective: The reported incidence of persistent hypoparathyroidism varies widely, and consensus on a definition is lacking. The objective was to evaluate the real-life incidence of persistent hypoparathyroidism by investigating a new pragmatic definition. Methods: This retrospective multicenter cohort study evaluated the effect of different definitions for persistent hypoparathyroidism on the incidence of hypoparathyroidism. In addition, risk factors for hypoparathyroidism were analyzed. Results: In total, 749 patients were included. Using the new pragmatic definition, we report an incidence of 7.9% of persistent hypoparathyroidism. When applying other commonly used definitions, incidence varied between 11.8% and 22.1%. Risk factors were parathyroid autotransplantation, presence of another surgical complication, and low postoperative serum calcium. Conclusions: Our data show that the incidence of persistent hypoparathyroidism in the literature may vary through the use of different definitions. This study indicates that a new pragmatic definition of persistent hypoparathyroidism has the potential to enable unbiased comparison between studies.

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APA

Lončar, I., van Kinschot, C. M. J., van Dijk, S. P. J., Franssen, G. J. H., Visser, E. E., Peeters, R. P., … van Ginhoven, T. M. (2022). Persistent post-thyroidectomy hypoparathyroidism: A multicenter retrospective cohort study. Scandinavian Journal of Surgery, 111(2). https://doi.org/10.1177/14574969221107282

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