Transcription, chromatin condensation, and gene migration

Abstract

The binding of fluorescently tagged proteins to tandem DNA arrays has been instrumental in understanding nuclear organization and function. Through the use of more natural tandem DNA arrays, Hu et al. (Hu, Y., I. Kireev, M. Plutz, N. Ashourian, and A.S. Belmont. 2009. J. Cell Biol. 185:87-100) gain new insights into chromatin organization and dynamics, and into the association of splicing factors with active genes.