Convergent synthesis of deoxypropionates

Abstract

Metallacycle-mediated allylic alcohol-alkyne reductive cross-coupling is described as a convergent solution to the synthesis of deoxypropionates. This approach offers superior step-economy in comparison to available strategies based on multistep iterative chain elongation. The technique is demonstrated in a concise synthesis of the C1-C11 subunit of borrelidin, and a total synthesis of (-)-vittatalactone. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.