The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression

Abstract

Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation. © 2013 Landes Bioscience.