Utility of E-1-(4-Acetamidobenzoyl)-2-Oxirane Carboxylic Acid in Synthesis Some Fused Heterocycles and Spiro Compounds

Abstract

The present work deals with the reaction of 4-(4-Acetyl amino phenyl-4-oxobut-2-enoic acid (1) with hydrogen peroxide afforded oxirane derivative 2.The latter compound was treated with 2-amino-5-aryl-1,3,4-thiadiazole to yield imidazolo[2,1-b]thiadiazole derivatives 4.The new heterocyclic compounds 4 are used as a key starting materials to synthesize some hetrocycles include pyrrolo-thiadiazolo imidazole , pyridazinone and spiro derivatives .The behavior of the pyri-dazinone compounds towards different electrophilic and nucleophilic reagents were investigated. The structure of the newly synthesized compounds were elucidated by elemental analysis and spectroscopic data. Keywords 4-Acetamido phenyl-4-oxo-but-2-enoic acid , oxirane,imidazol[2,1-b]thiadiazole, Pyrrolo imidazole,spiro pyrazolo and isoxazolo imidazo thiadiazole,pyridazinone