Assessment of Cognitive Function using the Rowland Universal Dementia Assessment Scale (RUDAS) in Patients with Thalassemia

Abstract

Background: Cognitive impairment is frequently found in patients with thalassemia. Advanced age, chronic anemia, iron overload, and hypercoagulability are contributing factors for cognitive dysfunction. Objective: To determine the prevalence of cognitive impairment and clinical predictive factors in patients with thalassemia. Materials and Methods: A cross-sectional study was conducted in adult patients aged 18 years or older at Srinagarind Hospital, Khon Kaen University, Thailand, from March to October 2021. The RUDAS test was used to assess cognitive functions. The patients were classified into two was used to demonstrate the clinical predictive factors for cognitive impairment. Results: Conclusion: Assessment of cognitive function using the RUDAS test showed a high prevalence of cognitive impairment among thalassemic patients. Aging, low ADL score, and iron overload were significant associated factors with this condition. Cognitive screening should be performed in high-risk patients to modify their risk factors, which may prevent or suspend the progression of cognitive impairment.