ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ROSUVASTATIN BY USING SOLID DISPERSION TECHNIQUE

Abstract

In the present study, an attempt has been made to increase the solubility of Olmesartan by solid dispersion (SD) using physical mixtures (PM) and solvent evaporation (SE) technique with surface active carriers like sodium starch glycolate (SSG), crospovidone (CP), cros-carmellose sodium (CCS) and micro-crystalline cellulose (MCC) and to improve the dissolution of the drug. The effect of several variables such as type of surface active carrier used and drug:carrier ratios were studied. The evaluation (PM and SE) by SDs were done by solubility study and dissolution study. The improvement in dissolution of the drug was observed in all PM and SE dispersions as compared to that of the pure drug. The dissolution rate of Olmesartan was directly proportional to increment in proportion of the surface active carriers. The 100 per cent drug release was obtained from SDs (prepared by SE method) of Olmesartan:SSG (1:5), and Olmesartan:CP (1:5) in 40 and 50 minutes, respectively. However, SDs prepared using SSG showed faster dissolution rate.