Diastereoselective synthesis of non-proteinogenic α-amino acids

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Abstract

The synthesis of enantiomerically pure azatyrosine, tribromophenylalanine and trichlorophenylalanine is described, using two methods, diastereoselective alkylation and (or) diastereoselective protonation of chiral enolates.

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Lecointe, L., Rolland, V., Pappalardo, L., Roumestant, M. L., Viallefont, P., & Martinez, J. (2000). Diastereoselective synthesis of non-proteinogenic α-amino acids. Journal of Peptide Research, 55(4), 300–307. https://doi.org/10.1034/j.1399-3011.2000.00681.x

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