Metabolic Networks, Microbial Consortia, and Analogies to Smart Grids

Abstract

Metabolic network analysis is an accessible and versatile modeling approach for biology that has taken much inspiration from electric circuit analysis. After introducing its main concepts, we focus on numerical tools, such as optimization and sampling, to predict cellular features and behaviors at a large scale. Optimization approaches exploit that metabolic networks are shaped by evolution and are, thus, assumed to embed a fitness condition reflecting the environment that they evolved in. In the past ten years, there is a trend to generalize metabolic network analysis to consortia of interacting species. This raises technical questions on, for example, optimality in consortia but also more general ones on metabolic coevolution, information exchange, and adaptation. This suggests and allows us to explore interesting analogies to technological systems, specifically to smart grids.