Studies on Nepalese crude drugs. XXVIII. Chemical constituents of Bhote Khair, the underground parts of Eskemukerjea megacarpum HARA

Abstract

From the underground parts of Eskemukerjea megacarpum HARA, two new stilbenes (14, 15) were isolated, together with a known coumarin, 5,7-dihydroxycoumarin (1), a tyramine derivative, trans-feruloyltyramine (2), two pyrogallol derivatives, gallic acid (3) and β-glucogallin (4), four flavonoids, trifolin (5), hyperin (6), myricetin 3-O-β-D-galactopyranoside (7), and myricitrin (8), five stilbenes, resveratorol (9), astringenin (10), piceid (11) astringin (12), and resveratorol 3-O-β-D-(6-O-galloyl) glucopyranoside (13), a flavan-3-ol, (-)-epigallocatechin 3-O-gallate (16), two proanthocyanidins, catechin-(4α→8)-epigallocatechin 3-O-gallate (17) and epicatechin 3-O-gallate-(4β→8)-epigallocatechin 3-O-gallate (18), and an anthocyanin, idaein (19). Compounds 14 and 15 were identified as (E)-3,5,3′,4′-tetrahydroxystilbene 3-O-β-D-(6-O-galloyl) glucopyranoside and (E)-3,5,4′-trihydroxystilbene 3-O-β-D-(6-O- galloyl)glucopyranoside, respectively, based on spectral and chemical data. © 2006 Pharmaceutical Society of Japan.