PREDICTORS OF FAILED THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION

Abstract

objectives: Acute myocardial infarction(AMI) is becoming increasingly important problem in developing countries, and thrombolysis is the main modality of treatment here. About 25-50% of patients fail to achieve successful reperfusion and these patients have poor prognosis. Since alternative modes of reperfusion are available, it is important to identify them. This study was aimed at defining the extent of failed thrombolysis and identifying its demographic and clinical predictors Methods: 50 cases of thrombolysed AMI patients were studied. Failed thrombolysis considered if there is 50% resolution of ST-segment elevation after 90minutes of thrombolysis in single lead showing maximum ST elevation at presentation. The clinical predictors of the out come were assessed. Results: Of 50 patients studied 30(60%)achieved successful thrombolysis and 20(40%) failed. Mean time to thrombolysis from onset of symptom was 5.85