Advanced Sensing Performance towards Simultaneous Determination of Binary Mixture of Antihypertensives Using PANI–Cerium Oxide Nanoparticles as Modifier in Carbon Paste Incorporating Graphite and Silicon-Oil

Abstract

Present paper reports multianalyte electroanalysis of hypertensive having amlodipine and nebivolol molecules in a single dose. Amlodipine and Nebivolol exhibited oxidation peaks at 0.70 and 0.90 V respectively on the Graphite/Polyaniline-Cerium Oxide/Carbon paste electrode. The linearity range was 0.1 to 1.6 μ g ml −1 in Britton Robinson buffer (pH 8.0). The limit of detection was 20.0 ng ml −1 for Amlodipine and 30.0 ng ml −1 for Nebivolol and the limit of quantification was 80.0 ng ml −1 for Amlodipine and 100 ng ml −1 for Nebivolol respectively. These analytes were also determined in pharmaceutical formulation and human serum and good recovery was obtained for the developed method.