The association between inflammation and immunosuppression: Implications for ici biomarker development

Abstract

Evasion of immune destruction is considered one of the hallmarks of cancer. Chronic inflammation can enable immune escape by suppressing immune surveillance and permitting the development of tumors and creating a tumor microenvironment that sustains cancer. This includes generating mechanisms that prevent the effectiveness of anti-tumor treatment including immune checkpoint inhibitor therapy. In this review, we explore the interplay of inflammation and immunosuppression, their effects on the tumor microenviron-ment, and their implications for immune checkpoint inhibitor therapy particularly in the context of predictive biomarkers for their use.