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Comparative assessment of siRNA and shRNA off target effects: What is slowing clinical development

Cancer Gene Therapy
DOI: 10.1038/cgt.2009.53
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Abstract

This review considers comparisons of the off-target effects of siRNA to shRNA and their potential impact on the efficacy and toxicity of RNAi based therapeutics. © 2009 Nature Publishing Group All rights reserved.

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Rao, D. D., Senzer, N., Cleary, M. A., & Nemunaitis, J. (2009, November). Comparative assessment of siRNA and shRNA off target effects: What is slowing clinical development. Cancer Gene Therapy. https://doi.org/10.1038/cgt.2009.53

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