Abstract
The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.
Cite
CITATION STYLE
Weinstein, H. J., Griffin, T. W., Feeney, J., Cohen, H. J., Propper, R. D., & Sallan, S. E. (1982). Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside. Blood, 59(6), 1351–1353. https://doi.org/10.1182/blood.v59.6.1351.1351
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