Correlations between allelic polymorphism of TNFβ in 1069 locus and severe post-trauma sepsis

Abstract

Objective: To investigate the possible association between allelic polymorphism of tumor necrosis factor β (TNFβ) in 1069 locus and severe post-trauma sepsis in the Han Chinese of Jiangsu Province, China. Methods: We studied the polymorphism of single-base mutation of the TNFβ gene in 58 patients with severe post-trauma sepsis and 88 healthy controls, using polymerase chain reaction (PCR) amplification and polyacrylamide gel electrophoresis (PAGE) analyses. Results: The frequency of the TNFβ*2 allele in patients complicated with post-trauma sepsis was significantly higher than that in healthy controls (68.9% vs 55.1%, P=0.015, RR=1.73). Conclusion: Our results implied an association between an allelic polymorphism of TNFβ in 1069 locus and severe post-trauma sepsis susceptibility in a Chinese population. © 2011 by The American Society for Clinical Pathology.