Structural and functional characterization of biological macromolecules by mass spectrometry

Abstract

Mass spectrometry has widely been used as a tool for identification of proteins in the research fields of biochemistry and clinical chemistry because it can provide accurate information on molecular masses of biological molecules with a small amount of sample in a short time. If mass spectrometry is properly used, it can also give information on the tertiary structure or on the molecular interactions of biological macromolecules. The present paper focuses on the role of mass spectrometry as a tool for the investigation on the tertiary structure of proteins and on the biological molecular interactions that play essential roles in various biological events. © 2006 The Pharmaceutical Society of Japan.