Renal phosphate wasting due to tumor-induced osteomalacia: A frequently delayed diagnosis

Abstract

In our patient, TIO remained undiagnosed for several years. Careful metabolic evaluation and extensive investigations eventually led to the diagnosis, and TIO was cured by surgical removal of the offending tumor. We emphasize the importance of determining serum phosphorus and TmP/ GFR and considering TIO early in the differential diagnosis of unexplained persistent bone pain, apparent joint pain, muscle weakness, and spontaneous fractures. © 2009 International Society of Nephrology.