The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the hedgehog signaling pathway

Abstract

Background: Kto-Skd plays important roles in development. But the mechanism for how this complex regulates Hedgehog pathway is unknown. Results: Kto-Skd down-regulates ptc expression. Conclusion: Kto-Skd complex can regulate ptc expression by interacting with Ci. Significance: The finding that the Kto-Skd complex affects Hh pathway provides novel mechanistic insights into the regulation of A/P boundary formation in Drosophila wing discs. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.