A unique irregular hexagon was self-assembled using an organic donor clip (bearing terminal pyridyl units) and a complementary organometallic acceptor clip. The resulting metallamacrocycle was characterized by multinuclear NMR, mass spectrometry, and elemental analyses. Molecular modeling confirmed hexagonal shaped cavity for this metallamacrocycle which is a unique example of a discrete hexagonal framework self-assembled from only two building blocks. Cytotoxicity of the Pt-based acceptor tecton and the self-assembled PtII-based macrocycle was evaluated using three cancer cell lines and results were compared with cisplatin. Results confirmed a positive effect of the metallamacrocycle formation on cell growth inhibition.
CITATION STYLE
Singh, K., Gangrade, A., Bhowmick, S., Jana, A., Mandal, B. B., & Das, N. (2018). Self-assembly of a [1 + 1] ionic hexagonal macrocycle and its antiproliferative activity. Frontiers in Chemistry, 6(APR). https://doi.org/10.3389/fchem.2018.00087
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