Circulating and adipose levels of adipokines associated with insulin sensitivity in nonobese subjects with type 2 diabetes

Abstract

Context: The adipokines chemerin, dipeptidyl peptidase 4, and adiponectin influence insulin sensitivity. Whether their circulating levels and adipose secretion are altered in nonobese individuals with type 2 diabetes mellitus (T2DM) is unknown. Objective: The objective of this study was to investigate SC adipose secretion and serum levels of the three adipokines in relation to T2DM features. Design: Fourteen nonobese T2DM and 13 healthy men were investigated. Insulin sensitivity and glucose control were assessed by hyperinsulinemic euglycemic clamp, homeostasis model assessment, and glycated hemoglobin. Main Outcome Measure: Association of circulating and adipose-secreted adipokines with fat cell volume and insulin sensitivity was measured. Participants: Volunteers in an outpatient academic clinic participated. Results: Although adipose secretion was similar between the groups, serum chemerin was higher (70 ± 10 vs 50 ± 1 ng/ml; P