Role of hexafluoroisopropanol in C-H activation

Abstract

1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) has emerged as an attractive tool in developing and facilitating C-H activation/functionalizations. The hydrogen bond donating ability of this solvent coupled with its enhanced acidity and reduced nucleophilicity has played an integral part in boosting the reactivity and stereoselectivity of C-H functionalization reactions. Several C-H activation reactions necessitate the requirement of HFIP which plays a central role in developing these methodologies. Herein, this report showcases the importance of HFIP in developing C-H activation reactions in organic synthesis.