In vivo delivery of a fluorescent FPR2/ALXtargeted probe using focused ultrasound and microbubbles to image activated microglia

Abstract

To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders.