Edible Strip of Petai Peel ( Parkia speciosa Hassk) as an Innovation for the Treatment of Diabetes Mellitus

Abstract

Petai (Parkia speciosa Hassk.) or stink bean has been known as a folk medicine to treat inflammation, hypertension, kidney problems, and diabetes mellitus. Freeze-drying of petai peel contains phenol and flavonoid compounds. The edible strip is an innovative pharmaceutical dosage form that has a high level of effectiveness. The use of edible strips is increasingly leading to the exploration of herbal plants to increase the economic value of herbal medicine. This research aimed to determine the anti-diabetic effect of edible strip petai peel. This research is an experimental study-first, the extraction and screening of phytochemical content. The second step was the optimization of ESPP formula by using SLD and evaluation of its physical characteristics. The last step was comparing the anti-diabetic effect of IEPP with ESPP at 1 g/kg BW dose. The anti-diabetic effect was tested in alloxan-induced diabetes mellitus rats and analyzed statistically. The results showed that the IEPP contained flavonoid, saponin, and tannin compound. The HPMC K100M 40.8% and Propylene glycol 9.2% has pH 6, tensile strength 0.456±0.0005 N/m 2 , and elasticity 80.184±0.003 MPa. The anti-diabetic effect of IEPP has no significantly different from the ESPP in 1 g/kg BW, respectively (56.72± 2.059)%, and (57.98± 3.095)%.