Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma

Abstract

To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the tβr-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blockingDNA damage repair, invasion, mesenchymal transition and angiogenesis. © 2012 Landes Bioscience.