Association study of functional genetic variants of innate immunity related genes in celiac disease

Abstract

Background: Recent evidence suggest that the innate immune system is implicated in the early events of celiac disease (CD) pathogenesis. In this work for the first time we have assessed the relevance of different proinflammatory mediators typically related to innate immunity in CD predisposition. Methods: We performed a familial study in which 105 celiac families characterized by the presence of an affected child with CD were genotyped for functional polymorphisms located at regulatory regions of 1L-1 α, 1L-1 β, 1L-1RN, 1L-18, RANTES and MCP-1 genes. Familial data was analysed with a transmission disequilibrium test (TDT) that revealed no statistically significant differences in the transmission pattern of the different genetic markers considered. Results: The TDT analysis for 1L-1 α, 1L-1 β, 1L-1RN, 1L-18, and MCP-1 genes genetic variants did not reveal biased transmission to the affected offspring. Only a borderline association of RANTES promoter genetic variants with CD predisposition was observed. Conclusion: Our results suggest that the analysed polymorphisms of 1L-1 α, 1L-1 β, 1L-1RN, 1L-18, RANTES and MCP-1 genes do not seem to play a major role in CD genetic predisposition in our population. © 2005 Rueda et al; licensee BioMed Central Ltd.