Changes in plasma cytokines after treatment of Ascaris lumbrkoides infection in individuals with HIV-1 infection

Abstract

Albendazole treatment of individuals with human immunodeficiency virus type 1 (HIV-1) and Ascaris lumbricoides coinfection has led to significantly improved CD4+ cell counts and a trend for lower plasma HIV-1 RNA levels in a previous randomized placebo-controlled trial. To define mechanisms by which deworming contributed to changes in markers of HIV-1 disease progression, plasma cytokine levels were evaluated. Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P = .04) but was not associated with significant changes in levels of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-13, interferon γ, tumor necrosis factor a, or thymic stromal lymphopoietin. Treatment of A. lumbricoides co-infection may delay HIV-1 disease progression by reducing helminth-in-duced, IL-10-mediated immunosuppression. © 2010 by the Infectious Diseases Society of America. All rights reserved.