Formulation and evaluation of gastro-retentive drug delivery system containing combination of glipizide and metformin hydrochloride

Abstract

Objective: Is to develop a gastroretentive drug delivery system of glipizide and metformin hydrochloride is to overcome the biggest problem in oral drug delivery is low and erratic drug bioavailability. Methods: Seven formulations containing retardant material and alkalizing agent were prepared with solubilizing agent in different ratios. The ability of various polymers to retain the drug when used in different concentrations was investigated. It was found that sodium bicarbonate reacts with HCl and produce CO2 which creates pores in tablet and elevates swelling by wetting polymer. Hence, it helps in maintaining the buoyancy. The release rate could be modified by varying the polymer ratio, concentration of alkalizing, and solubilizing agent. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, buoyancy, and in vitro dissolution studies. Results: The in vitro drug release profiles obtained for tablets (F2) made with combinations of hydroxypropyl methylcellulose (HPMC) K4M, HPMC, and K100M showed lesser floating lag time (<60 seconds) and a prolonged floating duration (>14 hrs) with controlled and sustained release of MHCl and GD. Conclusion: Controlled release floating drug delivery of GD and MHCl showed sufficient release for an extended period of time. As a result, the frequent dosing and possible incomplete absorption of drug can be avoided.