Abstract
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII. © 1995, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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CITATION STYLE
Ōtake, N., Kawai, H., Kamishohara, M., Odagawa, A., Suzuki, A., Uchida, T., & Kawasaki, T. (1995). Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives. The Journal of Antibiotics, 48(12), 1467–1480. https://doi.org/10.7164/antibiotics.48.1467
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