Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

Abstract

Zheng et al. show a distinct type of large platelets is specifically enriched in lung metastases but not in primary tumors. Identification of this cell type provides insight into the complexity of the metastatic tumor microenvironment. It also helps clarify confusion about the origin of endothelial progenitor cells.