Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein

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Abstract

The nonstructural protein (NS1 protein) of the influenza A virus binds to several types of RNAs. X-ray crystallographic analysis of the RNA-binding domain reveals a unique topology for the monomer as well as a novel six- helix structure for the dimer.

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Liu, J., Lynch, P. A., Chien, C. Y., Montelione, G. T., Krug, R. M., & Berman, H. M. (1997). Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nature Structural Biology, 4(11), 896–899. https://doi.org/10.1038/nsb1197-896

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