RETRACTED: Do phosphorylcholine-coated and uncoated oxygenators differ in terms of elicitation of cellular immune response during cardiopulmonary bypass surgery?

Abstract

Objective: Extracorporeal circulation and its systems have been known to increase the inflammatory response and cause protein absorption in coronary bypass surgery. In this study, we aimed to compare the affinities of phosphorylcholine-coated and uncoated oxygenators on the cellular inflammatory response and protein absorption.Methods: Twenty patients undergoing elective coronary bypass were randomly allocated into two groups: Phosphorylcholine-coated oxygenators were used in 10 patients (Group 1) and uncoated oxygenators were used in the other 10 patients (Group 2) during surgery. Samples were obtained from blood and oxygenators at the induction of anesthesia, the beginning and end of cardiopulmonary bypass (CPB) and postoperative 1st day. Parameters related with white blood cells were studied with flow cytometry and electron microscopy in these samples.Results: White blood cell and neutrophil counts were increased while platelet counts were significantly decreased in both groups postoperatively. CD3+ T cell levels were significantly decreased at the end of CPB and on postoperative day 1. CD3+ CD25+ T cell levels were found to be significantly lower in Group 2 on the 1st postoperative day. Electron microscopic evaluation demonstrated that phosphorylcholine-coated fibers were less likely to absorb blood components and proteins.Conclusion: Results of the current study have shown that phosphorylcholine-coated oxygenators were more likely to trigger a cellular immune response compared to the uncoated oxygenators.