Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis

Abstract

This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100μg/mL for 3,4-dichloro-N-phenyl- methyl-maleimide and 3,4-dichloro-N-phenyl-propil-maleimide and 200μg/mL for 3,4-dichloro-N-phenyl-maleimide, 3,4-dichloro-N-phenyl-ethyl-maleimide and 3,4-dichloro-N-phenyl-buthyl-maleimide.