Neuronal migration defects of the cerebral cortex: A destination debacle

Abstract

Disruptions in neuronal migration have been postulated as the basis for many cerebral malformations including lissencephaly, cortical heterotopia, and double cortex. Recently, the genetic basis for some of these disorders has been identified. In this review, we highlight recent advances in our understanding of the molecular mechanisms of neuronal migration and its relationship to cerebral cortical development and neuronal migration disorders. This has allowed us to begin categorizing specific malformations based on their molecular etiology.