Analytical performance of a fiber optic probe dissolution system

Abstract

A UV Fiber Optic Probe Dissolution System has been developed for the analysis of solid dosage forms. The system uses 12 dip-type fiber-optic probes coupled to 12 separate Photo Diode Array (PDA) spectrophotometers to acquire continuous dissolution curves in real time. The system is applicable to the analysis of both immediate and controlled-release formulations. The system is accurate, quicker, and easier to set up when compared with conventional HPLC or UV-sipper systems. The data is acquired, calculated, and secured using an in-house developed and validated software package. The software package uses a novel scatter-correction algorithm to generate accurate dissolution curves in a turbid medium. The data that the system generates is as accurate as the HPLC methods that it is replacing.