Synthesis of aliphatic hydroxyaryl ketones or (hetero)aryl hydroxyaryl ketones by acylation of organometallic reagents

Abstract

Diverse hydroxyarenecarboxylic acids afford stable N-(hydroxyaroyl) benzotriazoles that react with heteroaryl, alkyl, and aryl Grignard or lithium reagents to give the corresponding hydroxyaryl ketones in 51-94% yields. © Georg Thieme Verlag Stuttgart.