Fermentation of hemp seed proteins leads to formation of peptides that share sequence similarity with human vitamin D-binding protein

Abstract

In this article, we describe how fermentation of hemp seed proteins leads to formation of peptides that share sequence similarities with human vitamin D-binding protein. We compared the amino acid sequence of edestin, the major hexameric globular protein from hemp protein isolates, with that of human vitamin D-binding protein, and we found significant functional similarities. Among the different peptides formed during the process of fermentation, we identified the peptide VLANAFQ of edestin as a promising candidate showing a high degree of functional similarity as well a common pattern of hydrophobicity with the TPTELAKLVNKRSE peptide that is the active site of human vitamin D-binding protein as far as it immune-stimulating, anti-proliferative and anti-migration properties are concerned.