Anti-ulcer activity of Medicinal Herbs - A Review

Abstract

Background: Anxiety is a psychological and physiological state characterised by somatic, emotional and behavioural components with displeasing feeling of fear and concern. Aim and Objectives: In our study we have attempted to evaluate the antianxiety activity of zonisamide based on the serendipitious action in Swiss albino mice and also to study the histopathology of the brain hippocampal region. Materials and methods: The anxiolytic activity of test drug is evaluated with three animal models, Elevated pluz maze, Light dark exploration test and Hole board apparatus. Zonisamide (25mg/kg, 50mg/kg), Diazepam(1mg/kg), 0.5% Sodium carboxymethyl cellulose were given orally to the randomly divided 4 groups of six animals each. Number of entries and time spent in the ope n arm in the elevated pluz maze , time spent in the light arena of the light dark arena model and the number of nose poking behaviour in the hole board apparatus. Statistical analysis was done by ANOVA. Results: Zonisamide showed significant increase in the number of entries and the time spent in the light arena of the light dark model and elevated plus maze test. It also showed significant increase in number of nose poking in the hole board apparatus. Conclusion: Zonisamide has a potential clinical application in the management of anxiety disorders. It shows anxiolytic activity in three models.